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The dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may impair fertility in males and has been reported in 1. IBRANCE across PALOMA-2 and PALOMA-3. About Pfizer Oncology At Pfizer Oncology, we are committed to advancing medicines wherever we believe we can make a meaningful difference in the discovery, development and manufacture of health care desvenlafaxine pristiq products, including innovative medicines and biosimilars across more than 30 indications, including breast, genitourinary, colorectal, blood and lung cancers, as well as melanoma. For patients with disease progression following endocrine therapy.

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This extension does not include potential pediatric exclusivity. Monitor complete blood count prior to starting IBRANCE, at the beginning of each cycle, on Day 15 of first 2 cycles and as clinically indicated.

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